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5-Fluorouracil, which has a small molecular mass, low iipophilicty and poor permeability through BBB was chosen a model drug. Utilizing carboxylic aci ...展开
d as a carrer, we synthesized five N_1-Alkyl-5-Fluorouracil Derivatives in order to increase the lipophility of 5-Fluorouracil and transport by carrier system on the endothelium of the brain capillaries. By the mean of increasing the permeability through the BBB, the brain-targeted delivery was achieved. 收起
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